Enterobeta: Molecular mechanisms regulating the function and survival of pancreatic beta cells.
Although this is a newly established group, both lines of research are well consolidated given that both Dr. E. Fernández and Dr. Carlos Guillén have been part of the research team of two of the constituent groups of the former consortium MOIR-CM (Ref. S2010/BMD-2423; 2012-2016) and MOIR2-CM (Ref. B2017/BMD-3684; 2018-2022), namely, the ENMEPER group led by Dr. Fernando Escrivá Pons and the BETABRAIN group led by Dr. Manuel Benito de las Heras, respectively. The upcoming retirement of these senior researchers, along with the development of parallel topics with the same objective, the study of the molecular mechanisms involved in the etiopathogenesis of type 2 diabetes, has favored the convergence of both lines of research in the new constituent group of MOIR-ACTOME, ENTEROBETA, which brings a generational change to the entire consortium. The main lines of work are:
- The study of the impact of nutrition on the metabolic programming of tissues that are key to the control of glycemic homeostasis, with a special interest in the intertissue communication between intestine and pancreas, led by Dr. Elisa Fernández Millán (Associate Professor).
- The study of the control mechanisms of proliferation and death of pancreatic β cells, as well as different protective mechanisms, including both general autophagy and specific autophagy of certain altered or aging organelles, in response to oxidative stress or endoplasmic reticulum stress, directed by Dr. Carlos Guillén Viejo.
Funding for the last 5 years
- [2021-2025] MINISTERIO DE CIENCIA E INNOVACION. Identificacion de nuevos factores moduladores del Inflamasoma en las celulas beta pancreaticas. Comunicación Intertisular intestino-pancreas. PID2020-116134RB-I00. IP.: Elisa Fernández-Millán.
- [2016-2020] MINISTERIO DE ECONOMÍA Y COMPETITIVIDAD. Factores medioambientales implicados en el desarrollo del síndrome metabólico: restricción nutricional y microbiota intestinal. (BFU2016-77931-R) IP.:Carmen Álvarez Escolá.
- [2024-2025] Proyecto Intramural CIBERDEM 2024: Assessment of progression risk to type 2 diabetes in obese patients. Novel inflammatory molecules and extracellular vesicles as biomarkers in well- phenotypically characterized subjects using an innovative digital monitoring platform (Acronym RENDITIONS: Risk progrEssioN DIabeTes In Obese patieNtS). Ref. DEM2024/PIM01.
- [2022-2023] Proyecto Intramural CIBERDEM 2022: Identification of new therapeutic targets against β-cell glucolipotoxicity: focus on gut-derived metabolites from flavonoids. Ref. DEM2022/ PIM01.
- [2021-2024] MINISTERIO DE CIENCIA E INNOVACION. Papel de los exosomas portadores de amilina humana de las células beta pancreáticas en células neuronales. Conexión entre Diabetes y Alzheimer. PID2020-113361RB-I00. IP.: Carlos Guillén Viejo y Manuel Benito De las Heras
- [2018-2021] MINISTERIO DE ECONOMÍA, INDUSTRIA Y COMPETITIVIDAD. Papel de los mecanismos de dinámica y control de calidad mitocondriales en la amplificación de la termogénesis funcional o disfuncional. SAF2017-82133-R. IP.: Manuel Benito De las Heras
- [2018-2021] COMUNIDAD DE MADRID. Mecanismos moleculares y comunicación intertisular en la resistencia a la insulina. MOIR2-CM. S2017/BMD-3684. BETABRAIN. IP.: Manuel Benito De las Heras