La profesora Ángela Martínez Valverde (Grupo HEPIR) realizó una comunicación oral en el Cogreso Global NASH de Londres el pasadp 10 de febrero.

Effect of the hepatic extracellular vesicles in inflammation-associated insulin resistance in non-alcoholic fatty liver disease

Cell-to-cell communication by extracellular vesicles (EVs) is an emerging issue in non-alcoholic fatty liver disease (NAFLD). In this study we found higher EVs secretion, particularly exosomes, in
hepatocytes and plasma from obese mice with NAFLD compared with the controls from lean mice. Moreover, both the uptake of NAFLD-exosomes by macrophages in culture and intravenous injection of NAFLD-exosomes in mice triggered NFκB activation and a proinflammatory response. Insulin resistance was induced in hepatocytes incubated with the secretome of macrophages treated with NAFLD exosomes and in cultured hepatocytes
isolated from mice injected with NAFLD exosomes. Our results identified a novel molecular mechanism in the interactome
hepatocyte-macrophagehepatocyte where NAFLD exosomes (circulating or hepatocyte-derived) induced inflammation and insulin resistance through macrophages inflammatory responses.